Exercise and Duchenne muscular dystrophy: where we have been and where we need to go.
نویسندگان
چکیده
EXERCISE AND DUCHENNE MUSCULAR DYSTROPHY: WHERE WE HAVE BEEN AND WHERE WE NEED TO GO CHAD D. MARKERT, PhD, LAURA E. CASE, DPT, PCS, GREGORY T. CARTER, MD, MS, PATRICIA A. FURLONG, RN, BSN, MS, and ROBERT W. GRANGE, PhD Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA Division of Physical Therapy, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA Department of Clinical Neurosciences, Providence Medical Group, Olympia, Washington, USA 4 Parent Project Muscular Dystrophy, Middletown, Ohio, USA Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, Virginia, USA
منابع مشابه
P164: Adeno-Associated Viral Vectors in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
متن کاملDetection of the Duplication in Exons 56-63 of Duchenne Muscular Dystrophy Patients with MLPA
Background Duchenne Muscular Dystrophy (DMD) is a deadly X-linked recessive disorder. This genetic disorder affects 1 among 3,500-5,000 males in the world. The majority of the patients are male, due to the type of inheritance. It affects most of the skeletal, the respiratory, and cardiac muscles, causing these vital organs to contract and eventually mortality.<br...
متن کاملExercise and Duchenne muscular dystrophy: toward evidence-based exercise prescription.
To develop a rational framework for answering questions about the role of exercise in Duchenne muscular dystrophy (DMD), we focused on five pathophysiological mechanisms and offer brief hypotheses regarding how exercise may beneficially modulate pertinent cellular and molecular pathways. We aimed to provide an integrative overview of mechanisms of DMD pathology that may improve or worsen as a r...
متن کاملEffect of exercise on serum creatine kinase in carriers of Duchenne muscular dystrophy.
In order to evaluate the effect of exercise on serum creatine kinase levels, blood samples were obtained from 17 normal females and 12 Duchenne muscular dystrophy carriers before and 9 hours after moderately strenuous exercise. The results revealed that after exercise serum creatine kinase levels may be better indicators of carrier status than resting levels. The mean serum creatine kinase leve...
متن کاملGenetic linkage between the loci for colour blindness and Duchenne type muscular dystrophy.
Duchenne type muscular dystrophy is a condition which begins in infancy or early childhood, and is characterized by progressive muscle weakness leading to death in the late teens or early twenties (Walton and Nattrass, I954). This type of muscular dystrophy has been variously referred to as 'pseudohypertrophic muscular dystrophy' (Bell, I948), 'progressive muscular dystrophy of childhood' (Step...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Muscle & nerve
دوره 45 5 شماره
صفحات -
تاریخ انتشار 2012